Detalhe da pesquisa
1.
Structural basis for Cas9 off-target activity.
Cell
; 185(22): 4067-4081.e21, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306733
2.
Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a.
Nucleic Acids Res
; 52(2): 906-920, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38033317
3.
New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity.
Nucleic Acids Res
; 52(2): 921-939, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38033324
4.
Enhancement of CRISPR/Cas12a trans-cleavage activity using hairpin DNA reporters.
Nucleic Acids Res
; 50(14): 8377-8391, 2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35822842
5.
Substrate-independent activation pathways of the CRISPR-Cas9 HNH nuclease.
Biophys J
; 122(24): 4635-4644, 2023 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37936350
6.
Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification.
Int J Mol Sci
; 24(23)2023 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38069093
7.
GPU-Enhanced DFTB Metadynamics for Efficiently Predicting Free Energies of Biochemical Systems.
Molecules
; 28(3)2023 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36770943
8.
Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme.
Biochemistry
; 61(9): 785-794, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35420793
9.
Structural and dynamic insights into the HNH nuclease of divergent Cas9 species.
J Struct Biol
; 214(1): 107814, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34871741
10.
Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage.
J Chem Phys
; 157(22): 225103, 2022 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36546784
11.
All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome.
Proc Natl Acad Sci U S A
; 115(26): 6584-6589, 2018 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29891649
12.
Folding-upon-Repair DNA Nanoswitches for Monitoring the Activity of DNA Repair Enzymes.
Angew Chem Int Ed Engl
; 60(13): 7283-7289, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33415794
13.
Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain.
Q Rev Biophys
; 512018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30555184
14.
Mapping the Structural and Dynamic Determinants of pH-Sensitive Heparin Binding to Granulocyte Macrophage Colony Stimulating Factor.
Biochemistry
; 59(38): 3541-3553, 2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32897051
15.
Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics.
J Am Chem Soc
; 142(3): 1348-1358, 2020 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31885264
16.
Structure and Dynamics of the Acyl Chains in the Membrane Trafficking and Enzymatic Processing of Lipids.
Acc Chem Res
; 52(11): 3087-3096, 2019 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31364837
17.
Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a.
J Chem Inf Model
; 60(12): 6427-6437, 2020 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33107304
18.
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations.
Proc Natl Acad Sci U S A
; 114(28): 7260-7265, 2017 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28652374
19.
Understanding the mechanistic basis of non-coding RNA through molecular dynamics simulations.
J Struct Biol
; 206(3): 267-279, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30880083
20.
Structure and Dynamics of the CRISPR-Cas9 Catalytic Complex.
J Chem Inf Model
; 59(5): 2394-2406, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30763088